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KMID : 0380620070390030342
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Korean Journal of Food Science and Technology
2007 Volume.39 No. 3 p.342 ~ p.347
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Safety/Toxicology : Comparison of the Anti-inflammatory Effects of the Extracts from Rubus coreanus and Rubus occidentalis
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Yang Hyun-Mo
Lim Soon-Sung
Lee Yeon-Sil
Shin Hyun-Kyung
Oh Yang-Seok
Kim Jin-Kyung
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Abstract
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The dried fruit of the Rubus coreanus, which is well-known in Korea and referred to as ’Bokbunja,’ has been employed as a traditional medicine for centuries. This crude drug has been utilized in Korea for the management of impotence, spermatorrhea, enuresis, asthma, and allergic diseases. Our previous study demonstrated that the ethanol extracts of R. coreanus have anti-inflammatory effects. The principal objective of the present study was to conduct a comparison of the anti-inflammatory effects of the ethanol extracts of R. coreanus and R. occidentalis; here, we tested the unripe (URCE), half-ripened (HRCE), and ripened fruits (RCE) of R. coreanus, and the unripe (UROE), half-ripened (HROE), and ripened fruits (ROE) of R. occidentalis. We found that URCE, UROE, HRCE, and HROE reduced the production of nitric oxide and prostaglandin B2 as well as pro-inflammatory cytokines in lipopolysaccharide-stimulated RAW264.7 murine macrophages. Interestingly, the R. coreanus extracts showed stronger inhibitory effects on the production of these inflammatory mediators than the R. occidentalis extracts.
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KEYWORD
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Rubus coreanus, nitric oxide, prostaglandin E2, pro-inflammatory cytokines, macrophages
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